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Welcome to PharmCalc.com - The Android app is now here!
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| Gentamicin Calculator
(Under development) |
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Gentamicin Dose Calculator
Gentamicin Dosing Interval Calculator
Gentamicin Level Predictor
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Calculation(s) used
Calculation of Gentamicin dose
Dose determining weight
Ideal Body Weight is calculated from the patients height (using IBW
calculation), this is compared with the patients actual body weight.
If actual weight is > 20% of the IBW, then patient is classified as
obese and the adjusted body weight is used as the dose-determining weight
otherwise actual body weight is used.
Regime of 3mg/Kg is for Creatinine clearance of >15 mL/min and
<30mL/min, 5mg/Kg is used for creatinine clearance greater than
30mL/min.
Prediction of Plasma level
Aminoglycosides are cleared renally and so Cockgroft-Gault prediction of
GFR can be used to calculate their clearance in L/h.
Elimination rate constant, k is then calculated using Clearance and
volume of distribution.
Plasma concentration at time C1 can be calculated based on the Elimination
rate constant, k at time t1.
where
S=Salt fraction(=1),
F=Bioavailability (=1), Vd = Volume of Distribution (L/Kg)
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Notes
Gentamicin should not be used in the
following patient groups:
• Myasthenia Gravis
• Hypersensitvity to aminoglycosides
• Severe renal impairment
Once daily dosing should not be used in patients with:
• Infective Endocarditis
• Major Burns (>20% of body surface area)
• Pregnancy
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References
1. Winter, M.E., (2004). Basic
clinical pharmacokinetics. London: Lippincott, Williams and Williams.
2. Clinical Pharmacokinetics – Soraya Dhillon and Andrzej Kotstrzewski
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Copyright © 2006-2010 Jamie Al-Nasir, all rights reserved
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