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  Phenytoin oral dosing  
Weight (kg)
  Patient under 15yrs  
Target Steady state (μg/mL) {range 5-20}
Loading Dose (mg)
Maintenaince Dose (mg)

Calculation(s) used

Phenytoin follows saturation kinetics (non-linear): -



therefore maintenance dose R can be given by...


where
  Km = 5.7mg/L (Adults) or 3.2mg/L (children < 15)
  Vm = 450 * (W/70)0.6

Notes

 

References
1. Winter, M.E., (2004). Basic clinical pharmacokinetics. London: Lippincott, Williams and Williams.
2. N. Barber, A. Wilson (2007) Clinical Pharmacy, 2nd Edition. London, Elsevier
3. Clinical Pharmacokinetics Soraya Dhillon and Andrzej Kotstrzewski

Copyright 2006-2010 Jamie Al-Nasir, all rights reserved