Theophylline Oral dosing calculator (digitalisation)

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Theophylline oral dosing

Weight OR IBW (if Obese)	(kg)
	Heart Failure Liver Cirrhosis Severe Pulmonary Oedema	Smoker COPD Acute Pulmonary obstruction
Salt Factor	(fraction of 1) {Theophylline=1, Aminophylline~= 0.79, Choledyl=0.64}
Target Steady state	(ng/mL) {range 5-20}
Preferred dosing frequency
Loading Dose	(mg) {by slow IV injection}
Maintenaince Dose	(mg/12hrs)

Calculation(s) used

Vd = 0.5 L x W(Kg)
Cl = 0.04 L/hr/kg x Disease_factor

Theophylline

References
1. Winter, M.E., (2004). Basic clinical pharmacokinetics. London: Lippincott, Williams and Williams.
2. N. Barber, A. Wilson (2007) Clinical Pharmacy, 2nd Edition. London, Elsevier
3. Clinical Pharmacokinetics – Soraya Dhillon and Andrzej Kotstrzewski

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