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  Theophylline oral dosing  

Weight
OR IBW (if Obese)
(kg)
  Heart Failure
Liver Cirrhosis
Severe Pulmonary Oedema
Smoker
COPD
Acute Pulmonary obstruction
Salt Factor (fraction of 1)
{Theophylline=1, Aminophylline~= 0.79, Choledyl=0.64}
Target Steady state (ng/mL) {range 5-20}
Preferred dosing frequency
Loading Dose (mg) {by slow IV injection}
Maintenaince Dose (mg/12hrs)

Calculation(s) used

Vd = 0.5 L x W(Kg)
Cl = 0.04 L/hr/kg x Disease_factor

Theophylline

 

References
1. Winter, M.E., (2004). Basic clinical pharmacokinetics. London: Lippincott, Williams and Williams.
2. N. Barber, A. Wilson (2007) Clinical Pharmacy, 2nd Edition. London, Elsevier
3. Clinical Pharmacokinetics Soraya Dhillon and Andrzej Kotstrzewski

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