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  MDRD eGFR  

Age (years)
 Serum Creatinine

IDMS calibrated Creatinine
(see notes below)
  Female
Afro-Caribbean
Creatinine Clearance (mL/min/1.73 m2)
 

Calculation(s) used

eGFR  = 186 x (Screatinine)-1.154 x (Age)-0.203 x (0.742 if female) x (1.212 if Afro-Carribean)
where Screatinine in mg/dL

If IDMS calibrated creatinine used then eGFR = eGFR x (175/186)

CKD (Chronic Kidney Disease) severity staging

eGFR
(mL/min/1.73m2)		 Level of renal impairment
> 90
and No Proteinuria

Normal kidney function
>90
and evidence of renal damage		 CKD1
60 to 89 CKD2 (mild)
30 to 59 CKD3 (moderate)
15 to 29 CKD4 (severe)
<15 CKD5 (renal failure)


IDMS (Isotope Dilution Mass Spectrometry)

Some laboratories calibrate their Creatinine using the IDMS method in order to improve precision. This method may achieve a precision of 0.25%.[3]
 

References
1. Levey AS, Greene T, Kusek J, and Beck G. A simplified equation to predict glomerular filtration rate from serum creatinine (abstract). J Am Soc Nephrol. 2000. 11: p.155A.

2. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999 Mar 16;130(6):461–70.

3. EPA publication SW-846, "Test Methods for Evaluating Solid Waste, Physical/Chemical Methods", available at http://www.epa.gov/epaoswer/hazwaste/test/sw846.htm. See Method 6800, "Elemental and Speciated Isotope Dilution Mass Spectrometry"

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